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T14348 |
Auristatin E
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|
Microtubule Associated
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Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an... |
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T38889 |
Thailanstatin A
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|
|
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Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s... |
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T14349 |
Auristatin F
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|
Microtubule Associated
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Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates. |
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T11249L |
Dxd
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Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ |
Topoisomerase
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|
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. |
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T15141 |
DM4
|
Ravtansine |
Others
,
Microtubule Associated
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|
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. |
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T11120 |
Duocarmycin TM
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DNA Alkylation
,
Antibiotic
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Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. |
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T3256 |
MMAF
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MonoMethyl auristatin F |
Others
,
Microtubule Associated
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MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin. |
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T8003 |
Methotrexate disodium
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Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
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Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
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T12081 |
MMAF-OMe
|
Monomethyl auristatin F methyl ester |
|
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MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji ... |
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T1992 |
Mertansine
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DM1,Maytansinoid DM1 |
Microtubule Associated
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|
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4... |
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T6897 |
Monomethyl auristatin E
|
Vedotin,MMAE |
Apoptosis
,
Microtubule Associated
|
|
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity. |
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T16557 |
PNU-159682
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|
Topoisomerase
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PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin. |
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T21408 |
DM1-SMe
|
DM1-SSMe |
Microtubule Associated
|
|
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ... |
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T14858 |
Calicheamicin
|
Calicheamicin γ1 |
Others
|
|
|
|
T1910 |
Ansamitocin P 3'
|
Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3' |
Microtubule Associated
|
|
Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity. |
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T4677 |
MMAD
|
Monomethylauristatin D,Demethyldolastatin 10,Monomethyl Dolastatin 10 |
Microtubule Associated
|
|
MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs). |
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T1485 |
Methotrexate
|
NCI-C04671,WR19039,Amethopterin,CL14377 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... |
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T11917 |
Lys-SMCC-DM1
|
Lys-Nε-MCC-DM1 |
Microtubule Associated
|
|
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is the active metabolite of DM1. |
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T18701 |
SPDB-DM4
|
|
Others
|
|
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si... |
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T12149 |
N-Me-L-Ala-maytansinol
|
|
Others
|
|
N-Me-L-Ala-maytansinol used for making antibody-drug conjugate (ADC),is a hydrophobic, cell permeable payload. |
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T81144 |
SMP-93566
|
|
|
|
SMP-93566 is an antibody-drug conjugate (ADC) characterized by a low payload shedding rate, demonstrating in vivo tumor suppression in ovarian, gastric, and breast cancers [1]. |
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T15872 |
M-PEG4-Br
|
|
Others
|
|
m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrop... |
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T18477 |
NAMPT inhibitor-linker 1
|
|
Others
|
|
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong ef... |
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T79206 |
MC-EVCit-PAB-MMAE
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|
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MC-EVCit-PAB-MMAE (Linker-Payload 11), a conjugate utilized in antibody-drug conjugates (ADCs), comprises the MC-EVCit-PAB linker attached to the powerful tubulin polymerization inhibitor MMAE [1]. |
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T40049 |
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
|
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin |
|
|
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a mono... |
|
T77910 |
Patritumab deruxtecan
|
U3-1287,HER3-DXd |
|
|
Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleav... |
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T18478 |
NAMPT inhibitor-linker 2
|
|
Others
|
|
NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrate... |
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T74940 |
Anticancer agent 81
|
|
Apoptosis
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|
Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the antibody-agent conjugate (ADC) T-PBA. T-PBA retains the targeti... |
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T39458 |
DGN549-C
|
DGN549-C |
|
|
DGN549-C is a novel compound featuring a cleavable ADC (antibody-drug conjugate) linker composed of valine-alanine (va) and a PBD (pyrrolobenzodiazepine) dimer. This compound possesses a unique DNA-alkylating cytotoxic p... |
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T81146 |
SMP-33693
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|
|
|
SMP-33693 is an Antibody-Drug Conjugate (ADC) known for its low payload shedding rate and demonstrated in vivo tumor inhibition in ovarian, gastric, and breast cancers [1]. |
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T74562 |
Nampt-IN-10 trihydrochloride
|
|
|
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Nampt-IN-10 trihydrochloride (Compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor exhibiting cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. I... |
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T18522 |
PC Mal-NHS carbonate ester
|
|
Others
|
|
PC Mal-NHS carbonate ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. This chemical compound plays a crucial role in facilitating the conjugation of drugs to anti... |
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T78638 |
Clezutoclax
|
|
|
|
Clezutoclax, a potent Bcl-XL inhibitor, serves as an effective payload for the synthesis of antibody-drug conjugates (ADCs) [1]. |
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T75086 |
Dazostinag
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|
|
|
Dazostinag (TAK-676 free base) functions as a stimulator of interferon genes (STING) protein agonist, exhibiting antineoplastic properties. It also acts as a payload for the synthesis of antibody-drug conjugates (ADCs) [... |
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T75134 |
MC-GGFG-AM-(10Me-11F-Camptothecin)
|
|
|
|
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD... |
|
T38503 |
(2-pyridyldithio)-PEG1-hydrazine
|
(2-pyridyldithio)-PEG1-hydrazine |
|
|
(2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release... |
|
T82021 |
Izeltabart
|
IMGC-936 |
|
|
Izeltabart (IMGC-936) is a Maytansinoid-based Antibody-Drug Conjugate (ADC) that specifically targets ADAM9. It consists of a high-affinity humanized antibody conjugated site-specifically to DM21-C, a linker-payload that... |
